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An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
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References:
Briscoe A, Tamburri V, Cipollini C, et al. Use of tetrabenazine tromethamine as a local anaesthetic agent on open wounds at different sites in adult and pediatric
clotrimazole cream other names patients - an open-label pilot study. Br J Anaesth. 1988. 77(4):631-634.
Fagan P, Evers D, Cipollini C, et al. Diverse local and systemic pharmacokinetic, pharmacodynamic, tolerability profiles of bromophenothiazide (1,6-diphenylphthalazone) in man. Eur J Anaesth. 1995;16(1):41-48.
Fagan P. A double-blind placebo-controlled trial of 1,6-diphenyl-p-phthalazone for the treatment acute urinary incontinence in men and boys. Can J Urol. 1999;19(1):49-55.
Gillman A, Cipollini C, Chiuve B, et al. Effect of the antibiotic tetracycline (2.0 mg/kg, 10 mg/kg/day) versus placebo on plasma antibiotic concentration: a study with adult and pediatric patients. Clin Pharmacokinet. 1994;20(3):241-245.
Nguyen T, Tran C, Lee R, et al. Bactericidal therapy with tetracycline against multidrug-resistant organisms in pediatric emergency departments. J Pediatr Gastroenterol Nutr. 2012;5:2.
Nguyen T, Tran C, Gao A-M, et al. Antimicrobial effect of tetracycline in combination with rifampicin and erythromycin in an inpatient setting. Cochrane Database Syst Rev. 2007;(2):CD003567.
Nguyen T, Tran C, Lee R. Bactericidal treatment of multidrug-resistant organisms in pediatric emergency departments: a systematic review of literature. Cochrane Database Syst Rev. 2008;(3):CD004730.
Nguyen T, Tran C, Kim P-Y, et al. Efficacy of tetracycline versus rifampin, tigecycline, or gentamicin combined with vancomycin (1 g/kg/d) for the reduction of vancomycin-resistant Enterobacteriaceae in pediatric emergency departments. Vaccine. 2005;27(7):2941-2945.
Pérez-Aranda F, García-Alianza E, Pérez-Pascual A. Long-term tetracycline treatment in pediatric emergency clinics: a 10-year study of tetracycline-induced acute renal failure (ARF) in pediatric patients the presence of streptococcal infections. Pediatr Nephrol Dis. 2006;24(4):521-523.
Stokkan A, Sjofstad U, Vissing M, et al. The effects of short-term treatment with tetracycline and rifampicin on urinary tract infections and sepsis. J Pediatr. 1999;131(5 Pt 1):715-721.
Stokkan A, Rønnestad S, Lindholm M, et al. Tetracycline treatment causes adverse reactions in healthy persons, suggesting an immunotoxic effect of this compound. Scand J Infect Dis. 2001;29(5):421-433.
Trimipramine hydrochloride tablets - prescribing information
In May 2009, the European Medicines Agency (EMA) concluded that trimipramine hydrochloride tablets are of minimal benefit in adults with moderate-to-severe irritable bowel syndrome and that the potential of drug to cause severe renal toxicity in people who are already receiving intravenous (IV) catheters was present.
In May 2010, the US Food and Drug Administration determined that trimipramine hydrochloride tablets are of minimal risk and that prescribing them to adults was not associated with an increased risk of serious renal problems.